Methods of Sterilisation

Methods of Sterilisation The methods of sterilisation used in preparing the sterile materials described in the Pharmacopoeia are given in Appendix XVIII. For aqueous preparations, steam sterilisation (heating in an autoclave) is the method of choice wherever it is known to be suitable. Any method of sterilisation must be validated with respect to both the assurance of sterility and the integrity of the product and to ensure that the final product complies with the requirements of the monograph.