Abbreviations used in the monographs on immunoglobulins, immunosera and vaccines

Abbreviations used in the monographs on immunoglobulins, immunosera and vaccines
LD50 The statistically determined quantity of a substance that, when administered by the specified route, may be expected to cause the death of 50 per cent of the test animals within a given period
MLD Minimum lethal dose
L+/10 dose The smallest quantity of a toxin that, in the conditions of the test, when mixed with 0.1 IU of antitoxin and administered by the specified route, causes the death of the test animals within a given period
L+ dose The smallest quantity of a toxin that, in the conditions of the test, when mixed with 1 IU of antitoxin and administered by the specified route, causes the death of the test animals within a given period
lr/100 dose The smallest quantity of a toxin that, in the conditions of the test, when mixed with 0.01 IU of antitoxin and injected intracutaneously causes a characteristic reaction at the site of injection within a given period
Lp/10 dose The smallest quantity of toxin that, in the conditions of the test, when mixed with 0.1 IU of antitoxin and administered by the specified route, causes paralysis in the test animals within a given period
Lo/10 dose The largest quantity of a toxin that, in the conditions of the test, when mixed with 0.1 IU of antitoxin and administered by the specified route, does not cause symptoms of toxicity in the test animals within a given period
Lf dose The quantity of toxin or toxoid that flocculates in the shortest time with 1 IU of antitoxin
CCID50 The statistically determined quantity of virus that may be expected to infect 50 per cent of the cell cultures to which it is added
EID50 The statistically determined quantity of virus that may be expected to infect 50 per cent of fertilised eggs into which it is inoculated
ID50 The statistically determined quantity of a virus that may be expected to infect 50 per cent of the animals into which it is inoculated
PD50 The statistically determined dose of a vaccine that, in the conditions of the tests, may be expected to protect 50 per cent of the animals against a challenge dose of the micro-organisms or toxins against which it is active
ED50 The statistically determined dose of a vaccine that, in the conditions of the tests, may be expected to induce specific antibodies in 50 per cent of the animals for the relevant vaccine antigens
PFU Pock-forming units or plaque-forming units
SPF Specified-pathogen-free.